I love this. It's the implied setting of the original D&D books that came out in 1974 as detailed by Wayne Rossi in his blog. He says of it, "It is wild, and it feels profoundly like the world someone who watched every cheesy science fiction movie about giant monsters and every classic horror film would make."
That's what I want for my next campaign. I want fantasy and science fiction mixed together. I want the crazy tables of Dungeon Crawl Classics mixed with the crazy mutations of Mutant Future and everything in-between. It will start simply, with The Keep on the Borderlands. Who knows where it will go next?